Thématiques de recherche

• Neurophysiologie cellulaire
• Physiologie musculaire
• Toxicologie et modes d’action des insecticides
• Pharmacologie des canaux ioniques
• Comportement des abeilles

Brevets

1.  Patent # EP 3040345 A1 - Sodium channel subunits of pollinator insects and uses thereof (2016)
2.  Patent # WO2014155021 - Bee calcium channels and uses (2014)

Pour plus d'informations:

1. Article sur le site national d'INRAE : Toxicologie cellulaire in vitro
2. Article sur le site national d’INRAE : Phytopharmacovigilance

Livre

Les abeilles face au risque toxique. (2022). Collet, C., Sandoz, J.C., Charnet, P. CNRS Editions. ISBN 978-2-271-13724-1. 450 pp. Lien vers le site de l’éditeur

Chapitres de livre

Collet, C. (2022) Canaux calciques intracellulaires (RyR) de l’abeille domestique Apis mellifera. 25p. In: Collet, C., Sandoz, J.C., Charnet, P. (eds). Les abeilles face au risque toxique. CNRS Editions. ISBN 978-2-271-13724-1.

Collet, C., Raymond, V. (2022) Modes d’action neurotoxiques, cardiotoxiques et myotoxiques des insecticides chez l’abeille domestique Apis mellifera. 40p. In: Collet, C., Sandoz, J.C., Charnet, P. (eds). Les abeilles face au risque toxique. CNRS Editions. ISBN 978-2-271-13724-1.

Collet, C., Kadala, A., Charreton, M. (2022) Les effets des insecticides neurotoxiques sur la marche chez l’abeille domestique. 39p. In: Collet, C., Sandoz, J.C., Charnet, P. (eds). Les abeilles face au risque toxique. CNRS Editions. ISBN 978-2-271-13724-1.

Cens, T. Rousset, M., Thibaud, J.B., Menard, C. Collet, C., Chahine, M., Charnet, P.  (2017) Recent advances in the functional characterization of honeybee voltage-gated Ca2+ channels. In “Advances in Agrochemicals: G Protein-Coupled Receptors (GPCRs) and Ion Channels as Targets for Pest Control”. Chapter 5 : 75-89. American Chemical Society Books - DOI: 10.1021/bk-2017-1264.ch005.

Lefebvre R., Pouvreau S., Collet C., Allard B., Jacquemond V. (2014) Whole-Cell Voltage Clamp on Skeletal Muscle Fibers with the Silicone-Clamp Technique. In: Martina M., Taverna S. (eds) Patch-Clamp Methods and Protocols. Humana press. Methods in Molecular Biology 1183:159-70. DOI: 10.1007/978-1-4939-1096-0_9.

Publications récentes

1. Kaabeche, M., Charreton, M., Kadala, A., Mutterer, J. & Collet C. (2024) Cardiotoxicity of the diamide insecticide chlorantraniliprole in the intact heart and in isolated cardiomyocytes from the honey bee. Scientific Reports, 28 : 1498. DOI: 10.1038/s41598-024-65007-2.
2. Bertaud, A. Cens, T. Chavanieu , A., Estaran, S. Rousset, M. Soussi, L. Ménard, C., Kadala, A., Collet, C., Dutertre, S., Bois, P., Gosselin-Badaroudine, P., Thibaud, J.B., Roussel, J. Vignes, M. Chahine, M. & Charnet, P. (2024) Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels. Journal of General Physiology, 6 : e202313509. DOI: 10.1085/jgp.202313509.
3. Bertaud, A., Cens, T., Mary, R., Rousset, M., Arel, E., Thibaud, J.B., Vignes, M., Ménard, C., Dutertre, S., Collet, C., Charnet, P. (2022) Xenopus oocytes: a tool to decipher molecular specificity of insecticides towards mammalian and insect GABA-A receptors. Membranes, 12 : 440. DOI : 10.3390/membranes12050440.
4. Collet, C., Charreton, M., Szabo, L., Takacs, M., Csernoch, L., & Szentesi, P. (2021) Elementary calcium release events in the skeletal muscle cells of the honey bee Apis mellifera. Scientific Reports, 11 : 16731. DOI 10.1038/s41598-021-96028-w.
5. Henry, C., Cens, T., Charnet, P., Cohen-Solal, C., Collet, C., van-Dijk, J., Guiramand, J., de Jésus-Ferreira, M.C., Menard, C., Mokrane, N., Roussel, J., Thibault, J.B., Vignes, M. & Rousset, M. (2020) Heterogeneous expression of GABA receptor‐like subunits LCCH3 and GRD reveals functional diversity of GABA receptors in the honeybee Apis mellifera. British Journal of Pharmacology, 177 : 3924-3940. DOI 10.1111/bph.15135.
6. Kadala, A., Charreton, M., & Collet, C. (2020) Flubendiamide, the first phthalic acid diamide insecticide, impairs neuronal calcium signalling in the honey bee's antennae. Journal of Insect Physiology, 125 : 104086. DOI 10.1016/j.jinsphys.2020.104086.
7. Kadala, A., Charreton, M., Charnet, P., Collet, C. (2019). Honey bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations. Scientific Reports, 9 (1), 9 p. , DOI : 10.1038/s41598-019-39193-3
8.  Kadala, A., Charreton, M., Charnet, P., Cens, Rousset, Chahine, M., Vaissière, B., Collet, C. (2019). Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides. Scientific Reports, 9 (1), 12 p. , DOI : 10.1038/s41598-018-37278-z
9.  Ménard, C., Folacci, Brunello, Charreton, M., Collet, C., Mary, Rousset, Thibaud, Vignes, Charnet, Cens, T. (2018). Multiple combinations of RDL subunits diversify the repertoire of GABA receptors in the honey bee parasite Varroa destructor. Journal of Biological Chemistry, 293 (49), 19012-19024. , DOI : 10.1074/jbc.RA118.005365
10. Gosselin-Badaroudine, P., Charnet, P., Collet, C., Chahine, M. (Auteur de correspondance) (2017). Metaflumizone inhibits the honeybee NaV 1 channel by targeting recovery from slow inactivation. FEBS Letters, 591 (23), 3842-3849. , DOI : 10.1002/1873-3468.12897
11. Rousset M, Collet C, Cens T, Bastin F, Raymond V, Massou I, Menard C, Thibaud JB, Charreton M, Vignes M, Chahine M, Sandoz JC, Charnet P (2017)."Honeybee locomotion is impaired by Am-CaV3 low voltage-activated Ca2+ channel antagonist." Sci Rep 1;7:41782. doi: 10.1038/srep41782.
12.  Bordier C,  Suchail S,  Pioz M,  Devaud J-M,  Collet C,  Charreton M,  Le Conte Y, Alaux C (2017)."Stress response in honeybees is associated with changes in task-related physiology and energetic metabolism." Journal of Insect Physiology 98 : 47–54
13. Gosselin-Badaroudine, P., A. Moreau, L. Simard, T. Cens, M. Rousset, C. Collet, P. Charnet and M. Chahine (2016). "Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: Ca(V)4." Journal of General Physiology 148(2): 133-145.
14. Charreton, M., Decourtye, A., Henry, M., Rodet, G., Sandoz, J. C., Charnet, P., and Collet, C. (2015) A Locomotor Deficit Induced by Sublethal Doses of Pyrethroid and Neonicotinoid Insecticides in the Honeybee Apis mellifera. PLoS One 10, e0144879
15. Gosselin-Badaroudine, P., A. Moreau, L. Delemotte, T. Cens, C. Collet, M. Rousset, P. Charnet, M. L. Klein, and M. Chahine. (2015). Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides. Sci Rep 5:12475.
16.  Cens, T., M. Rousset, C. Collet, M. Charreton, L. Garnery, Y. Le Conte, M. Chahine, J. C. Sandoz, and P. Charnet. (2015). Molecular characterization and functional expression of the Apis mellifera voltage-dependent Ca2+ channels. Insect biochemistry and molecular biology 58:12-27.
17. Kadala, A., M. Charreton, I. Jakob, T. Cens, M. Rousset, M. Chahine, Y. Le Conte, P. Charnet, and C. Collet. (2014). Pyrethroids differentially alter voltage-gated sodium channels from the honeybee central olfactory neurons. PLoS One 9:e112194.

Liens vers la liste des publications :

• ORCID : https://orcid.org/0000-0002-4979-5911
• Archive HAL: https://cv.hal.science/claude-collet